SrasV1, Main, Exploration, bibRecord, 002A06

Suppression of Host Gene Expression by nsp1 Proteins of Group 2 Bat Coronaviruses ▿

Identifieur interne : 002A06 ( Main/Exploration ); précédent : 002A05; suivant : 002A07

Suppression of Host Gene Expression by nsp1 Proteins of Group 2 Bat Coronaviruses ▿

Auteurs : Yukinobu Tohya ; Krishna Narayanan ; Wataru Kamitani ; Cheng Huang ; Kumari Lokugamage ; Shinji Makino

Source :

Journal of Virology [ 0022-538X ] ; 2009.

RBID : PMC:2682096

Descripteurs français

KwdFr :
- Animaux, Chiroptera (virologie), Coronavirus (métabolisme), Coronavirus (physiologie), Données de séquences moléculaires, Humains, Infections à coronavirus (génétique), Infections à coronavirus (virologie), Interféron de type I (métabolisme), Lignée cellulaire, Phylogénie, Protéines virales non structurales (métabolisme), RNA replicase (métabolisme), Régulation de l'expression des gènes, Séquence d'acides aminés, Virus du SRAS (métabolisme), Virus du SRAS (physiologie).
MESH :
- génétique : Infections à coronavirus.
- métabolisme : Coronavirus, Interféron de type I, Protéines virales non structurales, RNA replicase, Virus du SRAS.
- physiologie : Coronavirus, Virus du SRAS.
- virologie : Chiroptera, Infections à coronavirus.
- Animaux, Données de séquences moléculaires, Humains, Lignée cellulaire, Phylogénie, Régulation de l'expression des gènes, Séquence d'acides aminés.

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Cell Line, Chiroptera (virology), Coronavirus (metabolism), Coronavirus (physiology), Coronavirus Infections (genetics), Coronavirus Infections (virology), Gene Expression Regulation, Humans, Interferon Type I (metabolism), Molecular Sequence Data, Phylogeny, RNA Replicase (metabolism), SARS Virus (metabolism), SARS Virus (physiology), Viral Nonstructural Proteins (metabolism).
MESH :
- chemical , metabolism : Interferon Type I, RNA Replicase, Viral Nonstructural Proteins.
- genetics : Coronavirus Infections.
- metabolism : Coronavirus, SARS Virus.
- physiology : Coronavirus, SARS Virus.
- virology : Chiroptera, Coronavirus Infections.
- Amino Acid Sequence, Animals, Cell Line, Gene Expression Regulation, Humans, Molecular Sequence Data, Phylogeny.

Abstract

nsp1 protein of severe acute respiratory syndrome coronavirus (SARS-CoV), a group 2b CoV, suppresses host gene expression by promoting host mRNA degradation and translation inhibition. The present study analyzed the activities of nsp1 proteins from the group 2 bat CoV strains Rm1, 133, and HKU9-1, belonging to groups 2b, 2c, and 2d, respectively. The host mRNA degradation and translational suppression activities of nsp1 of SARS-CoV and Rm1 nsp1 were similar and stronger than the activities of the nsp1 proteins of 133 and HKU9-1. Rm1 nsp1 expression in trans strongly inhibited the induction of type I interferon (IFN-I) and IFN-stimulated genes in cells infected with an IFN-inducing SARS-CoV mutant, while 133 and HKU9-1 nsp1 proteins had relatively moderate IFN-inhibitory activities. The results of our studies suggested a conserved function among nsp1 proteins of SARS-CoV and group 2 bat CoVs.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682096

DOI: 10.1128/JVI.02485-08
PubMed: 19264783
PubMed Central: 2682096

Affiliations:

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<front><div type="abstract" xml:lang="en"><p>nsp1 protein of severe acute respiratory syndrome coronavirus (SARS-CoV), a group 2b CoV, suppresses host gene expression by promoting host mRNA degradation and translation inhibition. The present study analyzed the activities of nsp1 proteins from the group 2 bat CoV strains Rm1, 133, and HKU9-1, belonging to groups 2b, 2c, and 2d, respectively. The host mRNA degradation and translational suppression activities of nsp1 of SARS-CoV and Rm1 nsp1 were similar and stronger than the activities of the nsp1 proteins of 133 and HKU9-1. Rm1 nsp1 expression in <italic>trans</italic>
 strongly inhibited the induction of type I interferon (IFN-I) and IFN-stimulated genes in cells infected with an IFN-inducing SARS-CoV mutant, while 133 and HKU9-1 nsp1 proteins had relatively moderate IFN-inhibitory activities. The results of our studies suggested a conserved function among nsp1 proteins of SARS-CoV and group 2 bat CoVs.</p>
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Suppression of Host Gene Expression by nsp1 Proteins of Group 2 Bat Coronaviruses ▿

Suppression of Host Gene Expression by nsp1 Proteins of Group 2 Bat Coronaviruses ▿

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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